Version 5.4
| Bos taurus Gene: PKLR | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-632071.3 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | PKLR | ||||||||||||||
| Gene Name | pyruvate kinase isozymes R/L | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Bos taurus | ||||||||||||||
| Ensembl Gene | ENSBTAG00000017056 | ||||||||||||||
| Encoded Proteins |
pyruvate kinase isozymes R/L
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||
| Summary |
[Homo sapiens] PKLR is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of IRF3-dependent genes.
[Mus musculus] Pklr is recruited by hepatitis C virus early in infection as a sensor to trigger the induction of Irf3-dependent genes. (Demonstrated in human)
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| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143627:
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 3:15399755-15408994 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | |||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME | |||||||||||||||
| KEGG |
Glycolysis / Gluconeogenesis pathway
Pyruvate metabolism pathway
Purine metabolism pathway
Insulin signaling pathway pathway
Maturity onset diabetes of the young pathway
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
Type II diabetes mellitus pathway
Insulin signaling pathway pathway
Glycolysis / Gluconeogenesis pathway
Pyruvate metabolism pathway
Purine metabolism pathway
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| INOH |
Purine nucleotides nucleosides metabolism pathway
Glycolysis Gluconeogenesis pathway
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| PID NCI |
FOXA2 and FOXA3 transcription factor networks
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| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | Q1JPG7 | ||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 539579 | ||||||||||||||
| UniGene | Bt.61163 | ||||||||||||||
| RefSeq | NM_001076176 XM_005203740 | ||||||||||||||
| HUGO | |||||||||||||||
| OMIM | |||||||||||||||
| CCDS | |||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | BT025386 DAAA02007155 | ||||||||||||||
| GenPept | ABF57342 | ||||||||||||||
| RNA Seq Atlas | 539579 | ||||||||||||||