Version 5.4
Mus musculus Gene: Atg3
Summary
InnateDB Gene IDBG-162821.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg3
Gene Name autophagy related 3
Synonyms 2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96
Species Mus musculus
Ensembl Gene ENSMUSG00000022663
Encoded Proteins
IDBP-162823
autophagy-related 3 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144848:
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy (Tanida et al., 2002 [PubMed 11825910]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:45158785-45188538
Strand Forward strand
Band B5
Transcripts
ENSMUST00000023343 ENSMUSP00000023343
ENSMUST00000150390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019776 Atg8 ligase activity
GO:0019777 Atg12 ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0019899 enzyme binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006464 cellular protein modification process
GO:0006914 autophagy
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0000153 cytoplasmic ubiquitin ligase complex
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000144848
View Gene Order
ENSBTAG00000009084
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.476283
RefSeq NM_026402
OMIM
CCDS CCDS28194
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca