Version 5.4
Homo sapiens Gene: ATG3
Summary
InnateDB Gene IDBG-49891.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG3
Gene Name autophagy related 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144848
Encoded Proteins
IDBP-49893
ATG3 autophagy related 3 homolog (S. cerevisiae)
IDBP-295230
ATG3 autophagy related 3 homolog (S. cerevisiae)
IDBP-473530
ATG3 autophagy related 3 homolog (S. cerevisiae)
IDBP-473434
ATG3 autophagy related 3 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy (Tanida et al., 2002 [PubMed 11825910]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:112532509-112562046
Strand Reverse strand
Band q13.2
Transcripts
ENST00000283290 ENSP00000283290
ENST00000402314 ENSP00000385943
ENST00000494571
ENST00000495756
ENST00000467275
ENST00000496423 ENSP00000420259
ENST00000492886 ENSP00000420378
ENST00000465980
ENST00000488910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 39 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019776 Atg8 ligase activity
GO:0019777 Atg12 ligase activity
GO:0019787 small conjugating protein ligase activity
GO:0019899 enzyme binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006464 cellular protein modification process
GO:0006612 protein targeting to membrane
GO:0006914 autophagy
GO:0016567 protein ubiquitination
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0044804 nucleophagy
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0000153 cytoplasmic ubiquitin ligase complex
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022663
View Gene Order
ENSBTAG00000009084
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477126 Hs.639931
RefSeq NM_001278712 NM_022488
HUGO
OMIM
CCDS CCDS2966 CCDS63721
HPRD 10654
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca