InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lsm4

Summary

InnateDB Gene

IDBG-163812.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lsm4

Gene Name

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031848

Encoded Proteins

IDBP-163814

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

IDBP-531670

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130520:
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3\'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:70673248-70678752

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000034311	ENSMUSP00000034311
ENSMUST00000146972	ENSMUSP00000121019
ENSMUST00000153689

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008150	biological_process
GO:0008380	RNA splicing

Cellular Component

GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130520

View Gene Order

ENSBTAG00000008578

Not yet available

Pathways

NETPATH

REACTOME

REACT_261877

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_233572

Gene Expression pathway

REACT_235784

Deadenylation-dependent mRNA decay pathway

KEGG

mmu03018

RNA degradation pathway

mmu03040

Spliceosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20518

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

REACT_207715

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_226022

Gene Expression pathway

REACT_203426

Deadenylation-dependent mRNA decay pathway

KEGG

hsa03018

RNA degradation pathway

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_015816 XM_006509706

OMIM

CCDS

CCDS40374

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas