Version 5.4
Mus musculus Gene: Ikzf2
Summary
InnateDB Gene IDBG-164181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ikzf2
Gene Name IKAROS family zinc finger 2
Synonyms A730095J18Rik; Helios; Zfpn1a2; Znfn1a2
Species Mus musculus
Ensembl Gene ENSMUSG00000025997
Encoded Proteins
IDBP-164183
IKAROS family zinc finger 2
IDBP-789489
IKAROS family zinc finger 2
IDBP-789490
IKAROS family zinc finger 2
IDBP-789493
IKAROS family zinc finger 2
IDBP-789496
IKAROS family zinc finger 2
IDBP-789497
IKAROS family zinc finger 2
IDBP-789498
IKAROS family zinc finger 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030419:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:69531214-69687245
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000027146 ENSMUSP00000027146
ENSMUST00000190771 ENSMUSP00000139543
ENSMUST00000187184 ENSMUSP00000141075
ENSMUST00000190855 ENSMUSP00000140043
ENSMUST00000188110 ENSMUSP00000140069
ENSMUST00000191262 ENSMUSP00000139530
ENSMUST00000190016 ENSMUSP00000140378
ENSMUST00000187870
ENSMUST00000188919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000030419
View Gene Order
ENSBTAG00000037804
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011770 XM_006495959 XM_006495960 XM_006495961 XM_006495962 XM_006495963 XM_006495964 XM_006495965 XM_006495966 XM_006495967 XM_006495968
OMIM
CCDS CCDS15026
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca