Version 5.4
Bos taurus Gene: BT.104763
Summary
InnateDB Gene IDBG-643621.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.104763
Gene Name IKAROS family zinc finger 2 (Helios); Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000037804
Encoded Proteins
IDBP-696185
IKAROS family zinc finger 2 (Helios)
IDBP-696187
IKAROS family zinc finger 2 (Helios)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000030419:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:101527602-101706119
Strand Reverse strand
Band
Transcripts
ENSBTAT00000034358 ENSBTAP00000034255
ENSBTAT00000035854 ENSBTAP00000035721
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000030419
View Gene Order
ENSMUSG00000025997
View Gene Order
Cross-References
SwissProt
TrEMBL A0JNA9
UniProt Splice Variant
Entrez Gene
UniGene Bt.104763
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126590 DAAA02005831 DAAA02005832 DAAA02005833 DAAA02005834
GenPept AAI26591
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca