Version 5.4
Homo sapiens Gene: IKZF2
Summary
InnateDB Gene IDBG-80024.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKZF2
Gene Name IKAROS family zinc finger 2 (Helios)
Synonyms ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Species Homo sapiens
Ensembl Gene ENSG00000030419
Encoded Proteins
IDBP-80026
IKAROS family zinc finger 2 (Helios)
IDBP-80030
IKAROS family zinc finger 2 (Helios)
IDBP-80032
IKAROS family zinc finger 2 (Helios)
IDBP-80034
IKAROS family zinc finger 2 (Helios)
IDBP-388723
IKAROS family zinc finger 2 (Helios)
IDBP-388724
IKAROS family zinc finger 2 (Helios)
IDBP-388725
IKAROS family zinc finger 2 (Helios)
IDBP-388726
IKAROS family zinc finger 2 (Helios)
IDBP-388727
IKAROS family zinc finger 2 (Helios)
IDBP-388728
IKAROS family zinc finger 2 (Helios)
IDBP-388729
IKAROS family zinc finger 2 (Helios)
IDBP-388730
IKAROS family zinc finger 2 (Helios)
IDBP-388732
IKAROS family zinc finger 2 (Helios)
IDBP-388733
IKAROS family zinc finger 2 (Helios)
IDBP-388734
IKAROS family zinc finger 2 (Helios)
IDBP-388735
IKAROS family zinc finger 2 (Helios)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:212999691-213152427
Strand Reverse strand
Band q34
Transcripts
ENST00000342002 ENSP00000342876
ENST00000374327 ENSP00000363447
ENST00000374326 ENSP00000363446
ENST00000374319 ENSP00000363439
ENST00000457361 ENSP00000410447
ENST00000434687 ENSP00000412869
ENST00000451136 ENSP00000395203
ENST00000453575 ENSP00000411444
ENST00000412444 ENSP00000413680
ENST00000413091 ENSP00000402334
ENST00000439848 ENSP00000389548
ENST00000431520 ENSP00000396253
ENST00000433134 ENSP00000406783
ENST00000421754 ENSP00000399574
ENST00000452786 ENSP00000402132
ENST00000442445 ENSP00000390045
ENST00000484040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008150 biological_process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025997
View Gene Order
ENSBTAG00000037804
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.159115 Hs.604950 Hs.613931 Hs.618886
RefSeq NM_001079526 NM_016260 XM_005246383 XM_005246384 XM_005246385 XM_005246386 XM_006712366 XM_006712367 XM_006712368
HUGO
OMIM
CCDS CCDS2395 CCDS46507
HPRD 05872
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca