Mus musculus Gene: Kcnn1
Summary
InnateDB Gene IDBG-164576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnn1
Gene Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Synonyms AI854248; KCa2.1; SK1
Species Mus musculus
Ensembl Gene ENSMUSG00000002908
Encoded Proteins
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105642:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70842049-70857008
Strand Reverse strand
Band B3.3
Transcripts
ENSMUST00000110081 ENSMUSP00000105708
ENSMUST00000110078 ENSMUSP00000105705
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006813 potassium ion transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Potassium Channels pathway
Ca2+ activated K+ channels pathway
Neuronal System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Ca2+ activated K+ channels pathway
Neuronal System pathway
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9EQR3
TrEMBL Z4YL28
UniProt Splice Variant
Entrez Gene 84036
UniGene
RefSeq NM_032397 XM_006509804 XM_006509805 XM_006509807 XM_006509808 XM_006509811
OMIM
CCDS CCDS52578
HPRD
IMGT
MGI ID MGI:1933993
MGI Symbol Kcnn1
EMBL AC019302 AC162446 AF116525 AF297869 AF297870 AF303461 AF303462 AF303463 AF357239 AY258143 BC090622
GenPept AAG43216 AAH90622 AAK29550 AAK29551 AAK29552 AAK30363 AAK48900 AAP45948
RNA Seq Atlas 84036