Version 5.4
Homo sapiens Gene: KCNN1
Summary
InnateDB Gene IDBG-37508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNN1
Gene Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Synonyms hSK1; KCa2.1; SK1; SKCA1
Species Homo sapiens
Ensembl Gene ENSG00000105642
Encoded Proteins
IDBP-811174
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
IDBP-811179
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
IDBP-811182
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17951293-18000080
Strand Forward strand
Band p13.11
Transcripts
ENST00000222249 ENSP00000476519
ENST00000594192
ENST00000609922 ENSP00000477114
ENST00000615435 ENSP00000484926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002908
View Gene Order
ENSBTAG00000008626
Not yet available
Pathways
NETPATH
REACTOME
REACT_75896
Ca2+ activated K+ channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3780
UniGene
RefSeq NM_002248 XM_005259905 XM_005259906 XM_005259907
HUGO HGNC:6290
OMIM 602982
CCDS CCDS67611
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 3780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca