Version 5.4
Mus musculus Gene: Ech1
Summary
InnateDB Gene IDBG-164686.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ech1
Gene Name enoyl coenzyme A hydratase 1, peroxisomal
Synonyms AA617331
Species Mus musculus
Ensembl Gene ENSMUSG00000053898
Encoded Proteins
IDBP-164688
enoyl coenzyme A hydratase 1, peroxisomal
IDBP-532180
enoyl coenzyme A hydratase 1, peroxisomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104823:
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28825217-28832247
Strand Forward strand
Band B1
Transcripts
ENSMUST00000066264 ENSMUSP00000066092
ENSMUST00000154839
ENSMUST00000127590
ENSMUST00000124017
ENSMUST00000132376 ENSMUSP00000116992
ENSMUST00000143708
ENSMUST00000137834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104823
View Gene Order
ENSBTAG00000016313
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_016772 XM_006540172
OMIM
CCDS CCDS21057
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca