Version 5.4
Homo sapiens Gene: ECH1
Summary
InnateDB Gene IDBG-49591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECH1
Gene Name enoyl CoA hydratase 1, peroxisomal
Synonyms HPXEL
Species Homo sapiens
Ensembl Gene ENSG00000104823
Encoded Proteins
IDBP-49593
enoyl CoA hydratase 1, peroxisomal
IDBP-765097
IDBP-763895
IDBP-761271
IDBP-765486
IDBP-761527
IDBP-764413
IDBP-762729
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38815422-38832005
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221418 ENSP00000221418
ENST00000602115 ENSP00000470519
ENST00000594164 ENSP00000470839
ENST00000595567 ENSP00000472378
ENST00000601060
ENST00000597089
ENST00000596118
ENST00000597205 ENSP00000471738
ENST00000601778 ENSP00000472322
ENST00000597805
ENST00000598316
ENST00000598707
ENST00000601094 ENSP00000469354
ENST00000594391
ENST00000601333
ENST00000600178
ENST00000595470 ENSP00000470809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016853 isomerase activity
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053898
View Gene Order
ENSBTAG00000016313
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001398
HUGO
OMIM
CCDS CCDS33014
HPRD 02825
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca