InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: REC8

Summary

InnateDB Gene

IDBG-3616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REC8

Gene Name

REC8 homolog (yeast)

Synonyms

HR21spB; REC8L1; Rec8p

Species

Homo sapiens

Ensembl Gene

ENSG00000100918

Encoded Proteins

IDBP-587543

REC8 homolog (yeast)

IDBP-603037

REC8 homolog (yeast)

IDBP-595960

REC8 homolog (yeast)

IDBP-813149

REC8 meiotic recombination protein

IDBP-813153

REC8 meiotic recombination protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:24171853-24180257

Strand

Forward strand

Band

q12

Transcripts

ENST00000557806	ENSP00000453763
ENST00000560032
ENST00000560501	ENSP00000453506
ENST00000560823
ENST00000559797	ENSP00000452701
ENST00000558191
ENST00000559939
ENST00000558381
ENST00000620473	ENSP00000482546
ENST00000611366	ENSP00000482439
ENST00000619469
ENST00000619284
ENST00000619111

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0001556	oocyte maturation
GO:0007062	sister chromatid cohesion
GO:0007126	meiotic nuclear division
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009566	fertilization
GO:0030999	linear element assembly
GO:0072520	seminiferous tubule development

Cellular Component

GO:0000228	nuclear chromosome
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0000794	condensed nuclear chromosome
GO:0000795	synaptonemal complex
GO:0000800	lateral element
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0030893	meiotic cohesin complex
GO:0034991	nuclear meiotic cohesin complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002324

View Gene Order

ENSBTAG00000002705

Not yet available

Pathways

NETPATH

REACTOME

REACT_75792

Meiotic synapsis pathway

REACT_115566

Cell Cycle pathway

REACT_111183

Meiosis pathway

KEGG

hsa04114

Oocyte meiosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.419259

RefSeq

NM_001048205 NM_005132

HUGO

OMIM

CCDS

CCDS41932

HPRD

09739

IMGT

EMBL

GenPept

RNA Seq Atlas