Version 5.4
Mus musculus Gene: Fdx1
Summary
InnateDB Gene IDBG-164954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fdx1
Gene Name ferredoxin 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032051
Encoded Proteins
IDBP-164956
ferredoxin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:51943307-51963533
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000034552 ENSMUSP00000034552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0042446 hormone biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137714
View Gene Order
ENSBTAG00000011793
Not yet available
Pathways
NETPATH
REACTOME
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_227038
Endogenous sterols pathway
REACT_223561
Pregnenolone biosynthesis pathway
REACT_232343
Biological oxidations pathway
REACT_196619
Electron transport from NADPH to Ferredoxin pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
REACT_199053
Mitochondrial iron-sulfur cluster biogenesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_150128
Electron transport from NADPH to Ferredoxin pathway
REACT_150353
Mitochondrial iron-sulfur cluster biogenesis pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_211020
Pregnenolone biosynthesis pathway
REACT_209020
Endogenous sterols pathway
REACT_224048
Electron transport from NADPH to Ferredoxin pathway
REACT_215986
Mitochondrial iron-sulfur cluster biogenesis pathway
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_218176
Biological oxidations pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
REACT_219110
Cytochrome P450 - arranged by substrate type pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P46656
TrEMBL Q4FZG2 Q545P3
UniProt Splice Variant
Entrez Gene 14148
UniGene
RefSeq NM_007996
OMIM
CCDS CCDS23178
HPRD
IMGT
MGI ID MGI:103224
MGI Symbol Fdx1
EMBL AK004879 BC099518 BC132173 BC132175 CH466522 D43689 D43690 L29123
GenPept AAA74303 AAH99518 AAI32174 AAI32176 BAA07786 BAA07787 BAB23637 EDL25784
RNA Seq Atlas 14148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca