InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hdac8

Summary

InnateDB Gene

IDBG-165027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac8

Gene Name

histone deacetylase 8

Synonyms

2610007D20Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000067567

Encoded Proteins

IDBP-165029

histone deacetylase 8

IDBP-788016

histone deacetylase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147099:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:102284639-102505359

Strand

Reverse strand

Band

Transcripts

ENSMUST00000087916	ENSMUSP00000085226
ENSMUST00000154872	ENSMUSP00000138805
ENSMUST00000148481
ENSMUST00000137785
ENSMUST00000154024

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004407	histone deacetylase activity
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007062	sister chromatid cohesion
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0071922	regulation of cohesin localization to chromatin