Version 5.4
Bos taurus Gene: BT.90254
Summary
InnateDB Gene IDBG-635691.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.90254
Gene Name histone deacetylase 8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000046092
Encoded Proteins
IDBP-687544
histone deacetylase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147099:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:83228463-83475076
Strand Forward strand
Band
Transcripts
ENSBTAT00000063475 ENSBTAP00000054707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0031078 histone deacetylase activity (H3-K14 specific)
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032129 histone deacetylase activity (H3-K9 specific)
GO:0034739 histone deacetylase activity (H4-K16 specific)
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007062 sister chromatid cohesion
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071922 regulation of cohesin localization to chromatin
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000147099
View Gene Order
ENSMUSG00000067567
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_218274
Chromatin organization pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_257106
HDACs deacetylate histones pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
INOH
INOH website
TGF-beta signaling pathway
INOH website
TGF-beta signaling pathway
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL G3MYR9
UniProt Splice Variant
Entrez Gene 540666
UniGene Bt.90254
RefSeq NM_001076231
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02072645 DAAA02072646 DAAA02072647 DAAA02072648 DAAA02072649 DAAA02072650 DAAA02072651 DAAA02072652 DAAA02072653 DAAA02072654 DAAA02072655 DAAA02072656
GenPept
RNA Seq Atlas 540666
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca