InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Notch3

Summary

InnateDB Gene

IDBG-165099.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Notch3

Gene Name

notch 3

Synonyms

AW229011; hpbk; N3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038146

Encoded Proteins

IDBP-165101

Notch gene homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074181:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:32120820-32166880

Strand

Reverse strand

Band

Transcripts

ENSMUST00000087723

ENSMUSP00000085016

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0045596	negative regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048663	neuron fate commitment
GO:0050793	regulation of developmental process
GO:0072104	glomerular capillary formation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex