Version 5.4
Mus musculus Gene: Apbb2
Summary
InnateDB Gene IDBG-167349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apbb2
Gene Name amyloid beta (A4) precursor protein-binding, family B, member 2
Synonyms 2310007D03Rik; FE65L1; Rirl1; TR2L; Zfra
Species Mus musculus
Ensembl Gene ENSMUSG00000029207
Encoded Proteins
IDBP-167351
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-540904
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-535905
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-541398
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-540450
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-535116
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-540666
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-531744
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-535520
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-532168
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-534876
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-542600
amyloid beta (A4) precursor protein-binding, family B, member 2
IDBP-532400
amyloid beta (A4) precursor protein-binding, family B, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163697:
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer\'s disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:66298861-66618828
Strand Reverse strand
Band C3.1
Transcripts
ENSMUST00000087256 ENSMUSP00000084511
ENSMUST00000159786 ENSMUSP00000125211
ENSMUST00000160870 ENSMUSP00000123978
ENSMUST00000160775
ENSMUST00000162349 ENSMUSP00000123752
ENSMUST00000162955
ENSMUST00000159512 ENSMUSP00000124807
ENSMUST00000162366 ENSMUSP00000125116
ENSMUST00000161771
ENSMUST00000160054
ENSMUST00000160063 ENSMUSP00000123778
ENSMUST00000162401
ENSMUST00000160185
ENSMUST00000162382 ENSMUSP00000124139
ENSMUST00000161879 ENSMUSP00000125550
ENSMUST00000160103 ENSMUSP00000123766
ENSMUST00000162994 ENSMUSP00000125603
ENSMUST00000159357 ENSMUSP00000124127
ENSMUST00000161716 ENSMUSP00000124350
ENSMUST00000161936
ENSMUST00000159847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
Biological Process
GO:0001764 neuron migration
GO:0006355 regulation of transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0007411 axon guidance
GO:0030048 actin filament-based movement
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163697
View Gene Order
ENSBTAG00000027569
Not yet available
Cross-References
SwissProt
TrEMBL E0CYY8 E0CZ85
UniProt Splice Variant
Entrez Gene 11787
UniGene Mm.487723
RefSeq NM_001201413 NM_001201414 NM_001201415 NM_001201416 NM_009686 XM_006503688 XM_006503689 XM_006503690 XM_006503691 XM_006503692 XM_006503694
OMIM
CCDS CCDS51510 CCDS57344 CCDS57345 CCDS57346
HPRD
IMGT
MGI ID MGI:108405
MGI Symbol Apbb2
EMBL AC123049 AC131752 AC149587 AC165426
GenPept
RNA Seq Atlas 11787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca