InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab8a

Summary

InnateDB Gene

IDBG-167493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab8a

Gene Name

RAB8A, member RAS oncogene family

Synonyms

AA409338; Mel

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003037

Encoded Proteins

IDBP-167497

RAB8A, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25022365

Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167461:
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%%, 96%%, and 51%% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:72161200-72183904

Strand

Forward strand

Band

B3.3

Transcripts

ENSMUST00000003121	ENSMUSP00000003121
ENSMUST00000135613
ENSMUST00000128203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017137	Rab GTPase binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006904	vesicle docking involved in exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0015031	protein transport
GO:0032869	cellular response to insulin stimulus
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly
GO:0045087	innate immune response (InnateDB)
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048210	Golgi vesicle fusion to target membrane
GO:0051223	regulation of protein transport
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0030425	dendrite
GO:0030670	phagocytic vesicle membrane
GO:0031513	nonmotile primary cilium
GO:0036064	ciliary basal body
GO:0043025	neuronal cell body
GO:0045335	phagocytic vesicle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome