Version 5.4
Mus musculus Gene: Diap2
Summary
InnateDB Gene IDBG-170053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Diap2
Gene Name diaphanous homolog 2 (Drosophila)
Synonyms Dia3; Diaph2; Drf2; E430022I22Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000034480
Encoded Proteins
IDBP-170057
diaphanous homolog 2 (Drosophila)
IDBP-254122
diaphanous homolog 2 (Drosophila)
IDBP-622893
diaphanous homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147202:
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:129749742-130465834
Strand Forward strand
Band E3
Transcripts
ENSMUST00000037854 ENSMUSP00000039334
ENSMUST00000113320 ENSMUSP00000108946
ENSMUST00000127577
ENSMUST00000143668
ENSMUST00000155333
ENSMUST00000133457
ENSMUST00000167619 ENSMUSP00000131879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007292 female gamete generation
GO:0016043 cellular component organization
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0048477 oogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000147202
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.10763
RefSeq NM_172493 XM_006528581 XM_006528582
OMIM
CCDS CCDS53180
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca