Version 5.4
| Mus musculus Gene: Gzmm | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-170467.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Gzmm | ||||||||||
| Gene Name | granzyme M (lymphocyte met-ase 1) | ||||||||||
| Synonyms | Lmet1; MMET-1 | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000054206 | ||||||||||
| Encoded Proteins |
granzyme M (lymphocyte met-ase 1)
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation | |||||||||||
| Summary |
Gzmm cleaves Fadd to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens. (Demonstrated in human)
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| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] GZMM (granzyme M) cleaves BIRC5 and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.
[Homo sapiens] GZMM cleaves FADD to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197540:
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 10:79689020-79695261 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | C1 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Alternative complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Immune System pathway
Complement cascade pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | B7ZP17 O08643 Q9R1W6 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 16904 | ||||||||||
| UniGene | Mm.378960 | ||||||||||
| RefSeq | NM_008504 XM_006513275 XM_006513277 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS23984 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:99549 | ||||||||||
| MGI Symbol | Gzmm | ||||||||||
| EMBL | AB015726 AB015728 AC151828 BC139217 BC139218 BC145578 CH466553 L76741 | ||||||||||
| GenPept | AAB51606 AAI39218 AAI39219 AAI45579 BAA78334 BAA78336 EDL31677 | ||||||||||
| RNA Seq Atlas | 16904 | ||||||||||