Version 5.4
| Bos taurus Gene: BT.31474 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-645482.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | BT.31474 | ||||||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000002100 | ||||||||||||||||
| Encoded Proteins |
Uncharacterized protein
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||
| Summary |
[Homo sapiens] GZMM (granzyme M) cleaves BIRC5 and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.
[Homo sapiens] GZMM cleaves FADD to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens.
[Mus musculus] Gzmm cleaves Fadd to potentiate the killing efficacy of innate effector natural killer cells against tumor cells and intracellular pathogens. (Demonstrated in human)
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| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197540:
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 7:44797942-44803445 | ||||||||||||||||
| Strand | Forward strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME |
Alternative complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Immune System pathway
Complement cascade pathway
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| KEGG | |||||||||||||||||
| INOH | |||||||||||||||||
| PID NCI | |||||||||||||||||
| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | E1BP32 | ||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 512272 | ||||||||||||||||
| UniGene | Bt.31474 | ||||||||||||||||
| RefSeq | XM_002689139 XM_589755 | ||||||||||||||||
| HUGO | HGNC:4712 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | DAAA02020220 | ||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | 512272 | ||||||||||||||||