InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp4a

Summary

InnateDB Gene

IDBG-170932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp4a

Gene Name

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005553

Encoded Proteins

IDBP-170934

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

IDBP-626143

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

IDBP-626146

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105675:
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:30712209-30725535

Strand

Forward strand

Band

Transcripts

ENSMUST00000005692	ENSMUSP00000005692
ENSMUST00000167761
ENSMUST00000170371	ENSMUSP00000131964
ENSMUST00000171014	ENSMUSP00000127209
ENSMUST00000165410

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0010155	regulation of proton transport
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0042493	response to drug
GO:0045851	pH reduction
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105675

View Gene Order

ENSBTAG00000008777

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00190

Oxidative phosphorylation pathway

mmu04971

Gastric acid secretion pathway

mmu04966

Collecting duct acid secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

hsa04971

Gastric acid secretion pathway

hsa04966

Collecting duct acid secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9QNX7

UniProt Splice Variant

Entrez Gene

11944

UniGene

Mm.12821

RefSeq

NM_001290627 XM_006539485 NM_018731

OMIM

CCDS

CCDS71932 CCDS52182

HPRD

IMGT

MGI ID

MGI:88113

MGI Symbol

Atp4a

EMBL

AC167978

GenPept

RNA Seq Atlas

11944