InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMARCA5

Summary

InnateDB Gene

IDBG-39364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA5

Gene Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Synonyms

hISWI; hSNF2H; ISWI; SNF2H; WCRF135

Species

Homo sapiens

Ensembl Gene

ENSG00000153147

Encoded Proteins

IDBP-39366

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:143513463-143557486

Strand

Forward strand

Band

q31.21

Transcripts

ENST00000283131	ENSP00000283131
ENST00000515531
ENST00000508573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	117 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016887	ATPase activity
GO:0031491	nucleosome binding
GO:0042393	histone binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006200	ATP catabolic process
GO:0006302	double-strand break repair
GO:0006333	chromatin assembly or disassembly
GO:0006334	nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription, initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016584	nucleosome positioning
GO:0034080	centromere-specific nucleosome assembly
GO:0043044	ATP-dependent chromatin remodeling

Cellular Component

GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005677	chromatin silencing complex
GO:0016589	NURF complex
GO:0031010	ISWI-type complex
GO:0031213	RSF complex
GO:0043596	nuclear replication fork