InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CYP11A1

Summary

InnateDB Gene

IDBG-631847.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP11A1

Gene Name

cholesterol side-chain cleavage enzyme, mitochondrial precursor

Synonyms

CYP11A; CYPXIA1; P450(scc)

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006934

Encoded Proteins

IDBP-683426

cholesterol side-chain cleavage enzyme, mitochondrial precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140459:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:34724307-34734990

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009106

ENSBTAP00000009106

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding