Version 5.4
Mus musculus Gene: Ffar2
Summary
InnateDB Gene IDBG-171495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ffar2
Gene Name free fatty acid receptor 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000051314
Encoded Proteins
IDBP-171497
free fatty acid receptor 2
IDBP-626250
free fatty acid receptor 2
IDBP-626252
free fatty acid receptor 2
IDBP-788814
free fatty acid receptor 2
IDBP-788816
free fatty acid receptor 2
IDBP-788818
free fatty acid receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19865172
[Homo sapiens] FFAR2 binding of short chain fatty acids (SCFAs) provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126262:
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30818348-30823775
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000053156 ENSMUSP00000052600
ENSMUST00000168528 ENSMUSP00000129398
ENSMUST00000163504 ENSMUSP00000127758
ENSMUST00000186339 ENSMUSP00000140493
ENSMUST00000186534 ENSMUSP00000140215
ENSMUST00000186059 ENSMUSP00000140484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008289 lipid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126262
View Gene Order
ENSBTAG00000006566
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_198709
Free fatty acid receptors pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_21268
Free fatty acid receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001168509 NM_001168510 NM_001168511 NM_001168512 NM_146187
OMIM
CCDS CCDS21111
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca