Version 5.4
Homo sapiens Gene: FFAR2
Summary
InnateDB Gene IDBG-44260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FFAR2
Gene Name free fatty acid receptor 2
Synonyms FFA2R; GPR43
Species Homo sapiens
Ensembl Gene ENSG00000126262
Encoded Proteins
IDBP-44262
free fatty acid receptor 2
IDBP-765287
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19865172
FFAR2 binding of short chain fatty acids (SCFAs) provides a molecular link between diet, gastrointestinal bacterial metabolism, and immune and inflammatory responses.
Entrez Gene
Summary This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35443907-35451767
Strand Forward strand
Band q13.12
Transcripts
ENST00000246549 ENSP00000246549
ENST00000599180 ENSP00000473159
ENST00000601590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0008289 lipid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051314
View Gene Order
ENSBTAG00000006566
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_21268
Free fatty acid receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O15552
TrEMBL C6KYL4
UniProt Splice Variant
Entrez Gene 2867
UniGene Hs.248056
RefSeq NM_005306
HUGO HGNC:4501
OMIM 603823
CCDS CCDS12461
HPRD
IMGT
EMBL AB378083 AC002511 AF024690 BC095535 BC096198 BC096199 BC096200 BC096201 EU432114
GenPept AAB67886 AAB86713 AAH95535 AAH96198 AAH96199 AAH96200 AAH96201 ABY87913 BAH86809
RNA Seq Atlas 2867

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca