Version 5.4
Mus musculus Gene: Acvr1c
Summary
InnateDB Gene IDBG-172013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acvr1c
Gene Name activin A receptor, type IC
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026834
Encoded Proteins
IDBP-172015
activin A receptor, type IC
IDBP-172017
activin A receptor, type IC
IDBP-255655
activin A receptor, type IC
IDBP-255657
activin A receptor, type IC
IDBP-543020
activin A receptor, type IC
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123612:
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:58267453-58357895
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000100085 ENSMUSP00000097663
ENSMUST00000028178 ENSMUSP00000028178
ENSMUST00000112608 ENSMUSP00000108227
ENSMUST00000112607 ENSMUSP00000108226
ENSMUST00000154453 ENSMUSP00000119776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005524 ATP binding
GO:0016361 activin receptor activity, type I
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0038100 nodal binding
GO:0046872 metal ion binding
Biological Process
GO:0002021 response to dietary excess
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0009749 response to glucose
GO:0019915 lipid storage
GO:0023014 signal transduction by phosphorylation
GO:0030154 cell differentiation
GO:0030262 apoptotic nuclear changes
GO:0032868 response to insulin
GO:0038092 nodal signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046676 negative regulation of insulin secretion
GO:1901164 negative regulation of trophoblast cell migration
GO:1901383 negative regulation of chorionic trophoblast cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048179 activin receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123612
View Gene Order
ENSBTAG00000019337
Not yet available
Pathways
NETPATH
REACTOME
REACT_220645
Signaling by NODAL pathway
REACT_216258
Signaling by Activin pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150238
Signaling by Activin pathway
REACT_111059
Regulation of signaling by NODAL pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.400056 Mm.77751
RefSeq NM_001033369 NM_001111030 XM_006498086
OMIM
CCDS CCDS16049 CCDS50586
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca