InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mcl1

Summary

InnateDB Gene

IDBG-173221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcl1

Gene Name

myeloid cell leukemia sequence 1

Synonyms

AW556805; Mcl-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038612

Encoded Proteins

IDBP-173223

myeloid cell leukemia sequence 1

IDBP-716398

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143384:
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95658721-95663176

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000037947	ENSMUSP00000044048
ENSMUST00000178686	ENSMUSP00000135915

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	35 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637	apoptotic mitochondrial changes
GO:0030154	cell differentiation
GO:0034097	response to cytokine
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:2000811	negative regulation of anoikis
GO:2001020	regulation of response to DNA damage stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097136	Bcl-2 family protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000143384

View Gene Order

ENSBTAG00000015154

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

e2f_pathway

E2F transcription factor network

hif1_tfpathway

HIF-1-alpha transcription factor network

il6_7pathway

IL6-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.1639 Mm.413637 Mm.466578

RefSeq

NM_008562

OMIM

CCDS

CCDS57236

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas