Version 5.4
Bos taurus Gene: MCL1
Summary
InnateDB Gene IDBG-633351.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCL1
Gene Name induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015154
Encoded Proteins
IDBP-685049
myeloid cell leukemia sequence 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143384:
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:20172325-20176960
Strand Forward strand
Band
Transcripts
ENSBTAT00000020159 ENSBTAP00000020159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005741 mitochondrial outer membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143384
View Gene Order
ENSMUSG00000038612
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
e2f_pathway
E2F transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL A5PJR2
UniProt Splice Variant
Entrez Gene 788087
UniGene Bt.111548 Bt.59074
RefSeq NM_001099206 XM_005203957
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142209 DAAA02007259
GenPept AAI42210
RNA Seq Atlas 788087

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca