Version 5.4
Mus musculus Gene: Tbr1
Summary
InnateDB Gene IDBG-173844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbr1
Gene Name T-box brain gene 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000035033
Encoded Proteins
IDBP-173846
T-box brain gene 1
IDBP-173848
T-box brain gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136535:
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:61802930-61814114
Strand Forward strand
Band C1.3
Transcripts
ENSMUST00000048934 ENSMUSP00000046787
ENSMUST00000102737 ENSMUSP00000099798
ENSMUST00000136867
ENSMUST00000131538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007411 axon guidance
GO:0010092 specification of organ identity
GO:0010468 regulation of gene expression
GO:0010975 regulation of neuron projection development
GO:0030182 neuron differentiation
GO:0030902 hindbrain development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136535
View Gene Order
ENSBTAG00000021692
Not yet available
Cross-References
SwissProt Q64336
TrEMBL Q3TY75
UniProt Splice Variant
Entrez Gene 21375
UniGene Mm.308525 Mm.404741
RefSeq NM_009322 XM_006499098
OMIM
CCDS CCDS16063
HPRD
IMGT
MGI ID MGI:107404
MGI Symbol Tbr1
EMBL AK158835 AL845291 BC052737 BC058399 CH466519 U49251
GenPept AAA92011 AAH52737 AAH58399 BAE34688 CAM17335 EDL26982
RNA Seq Atlas 21375

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca