Version 5.4
Mus musculus Gene: Gcg
Summary
InnateDB Gene IDBG-174026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcg
Gene Name glucagon
Synonyms GLP-1; Glu; PPG
Species Mus musculus
Ensembl Gene ENSMUSG00000000394
Encoded Proteins
IDBP-174028
glucagon
IDBP-535572
glucagon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115263:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:62474530-62483650
Strand Reverse strand
Band C1.3
Transcripts
ENSMUST00000102733 ENSMUSP00000099794
ENSMUST00000136686 ENSMUSP00000115892
ENSMUST00000155624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031769 glucagon receptor binding
GO:0042802 identical protein binding
Biological Process
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0010737 protein kinase A signaling
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042594 response to starvation
GO:0043066 negative regulation of apoptotic process
GO:0045722 positive regulation of gluconeogenesis
GO:0045860 positive regulation of protein kinase activity
GO:0050796 regulation of insulin secretion
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090280 positive regulation of calcium ion import
GO:1900118 negative regulation of execution phase of apoptosis
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0034774 secretory granule lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115263
View Gene Order
ENSBTAG00000000730
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_231304
Glucagon-type ligand receptors pathway
REACT_223625
GPCR downstream signaling pathway
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_254215
Signaling by GPCR pathway
REACT_210399
Glucagon signaling in metabolic regulation pathway
REACT_250061
Class B/2 (Secretin family receptors) pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_263148
Regulation of insulin secretion pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_231468
GPCR ligand binding pathway
REACT_233293
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_248547
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_205221
Incretin synthesis, secretion, and inactivation pathway
REACT_209110
Regulation of insulin secretion pathway
REACT_220607
Glucagon-type ligand receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_206064
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_223503
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_217101
Integration of energy metabolism pathway
REACT_214353
Signal Transduction pathway
REACT_213782
Metabolism of proteins pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_219139
Metabolism pathway
REACT_217846
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_221707
Glucagon signaling in metabolic regulation pathway
REACT_204109
Class B/2 (Secretin family receptors) pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P55095
TrEMBL A2AS86
UniProt Splice Variant
Entrez Gene 14526
UniGene Mm.471026
RefSeq NM_008100 XM_006498770
OMIM
CCDS CCDS16066
HPRD
IMGT
MGI ID MGI:95674
MGI Symbol Gcg
EMBL AF276754 AK007911 AK148544 AL928576 BC012975 Z46845
GenPept AAH12975 AAK96898 BAB25344 BAE28612 CAA86902
RNA Seq Atlas 14526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca