Bos taurus Gene: GCG | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-641235.3 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | GCG | ||||||||||||||||||||||||||||||||||
Gene Name | Glucagon Glicentin Glicentin-related polypeptide Oxyntomodulin Glucagon Glucagon-like peptide 1 Glucagon-like peptide 1(7-37) Glucagon-like peptide 1(7-36) Glucagon-like peptide 2 | ||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000000730 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
GlucagonGlicentinGlicentin-related polypeptideOxyntomodulinGlucagonGlucagon-like peptide 1Glucagon-like peptide 1(7-37)Glucagon-like peptide 1(7-36)Glucagon-like peptide 2
GlucagonGlicentinGlicentin-related polypeptideOxyntomodulinGlucagonGlucagon-like peptide 1Glucagon-like peptide 1(7-37)Glucagon-like peptide 1(7-36)Glucagon-like peptide 2
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115263:
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:34398011-34408391 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Peptide hormone metabolism pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Incretin synthesis, secretion, and inactivation pathway
Regulation of insulin secretion pathway
Glucagon-type ligand receptors pathway
Signaling by GPCR pathway
G alpha (s) signalling events pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Integration of energy metabolism pathway
Signal Transduction pathway
Metabolism of proteins pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Metabolism pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
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KEGG | |||||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (s) signalling events pathway
Glucagon-type ligand receptors pathway
Class B/2 (Secretin family receptors) pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Metabolism of proteins pathway
GPCR ligand binding pathway
Metabolism pathway
Peptide hormone metabolism pathway
G alpha (s) signalling events pathway
Glucagon-type ligand receptors pathway
GPCR downstream signaling pathway
Incretin synthesis, secretion, and inactivation pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Class B/2 (Secretin family receptors) pathway
Integration of energy metabolism pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
Metabolism pathway
Metabolism of proteins pathway
Regulation of insulin secretion pathway
Peptide hormone metabolism pathway
GPCR ligand binding pathway
Synthesis, secretion, and deacylation of Ghrelin pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
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KEGG | |||||||||||||||||||||||||||||||||||
INOH |
GPCR signaling pathway
GPCR signaling pathway
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PID NCI |
FOXA1 transcription factor network
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Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
UniGene | Bt.410 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_173916 XM_005202403 | ||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||