Version 5.4
Mus musculus Gene: Fap
Summary
InnateDB Gene IDBG-174084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fap
Gene Name fibroblast activation protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000000392
Encoded Proteins
IDBP-174086
fibroblast activation protein
IDBP-174088
fibroblast activation protein
IDBP-627553
fibroblast activation protein
IDBP-627555
fibroblast activation protein
IDBP-627556
fibroblast activation protein
IDBP-627560
fibroblast activation protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:62500943-62574075
Strand Reverse strand
Band C1.3
Transcripts
ENSMUST00000102732 ENSMUSP00000099793
ENSMUST00000000402 ENSMUSP00000000402
ENSMUST00000152085
ENSMUST00000128139 ENSMUSP00000134074
ENSMUST00000136297
ENSMUST00000174234 ENSMUSP00000133792
ENSMUST00000174448 ENSMUSP00000134386
ENSMUST00000172676
ENSMUST00000173745 ENSMUSP00000134305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0043542 endothelial cell migration
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031258 lamellipodium membrane
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0071438 invadopodium membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078098
View Gene Order
ENSBTAG00000008140
Not yet available
Cross-References
SwissProt
TrEMBL G3UZ14
UniProt Splice Variant
Entrez Gene 14089
UniGene Mm.41816
RefSeq NM_007986 XM_006498746
OMIM
CCDS CCDS16067
HPRD
IMGT
MGI ID MGI:109608
MGI Symbol Fap
EMBL AL928576
GenPept
RNA Seq Atlas 14089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca