Version 5.4
Homo sapiens Gene: FAP
Summary
InnateDB Gene IDBG-73736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAP
Gene Name fibroblast activation protein, alpha
Synonyms DPPIV; FAPA
Species Homo sapiens
Ensembl Gene ENSG00000078098
Encoded Proteins
IDBP-73738
fibroblast activation protein, alpha
IDBP-387024
fibroblast activation protein, alpha
IDBP-387028
fibroblast activation protein, alpha
IDBP-387029
fibroblast activation protein, alpha
IDBP-387030
fibroblast activation protein, alpha
IDBP-593996
fibroblast activation protein, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:162170684-162245151
Strand Reverse strand
Band q24.2
Transcripts
ENST00000188790 ENSP00000188790
ENST00000422436 ENSP00000417028
ENST00000443424 ENSP00000411391
ENST00000447386 ENSP00000400137
ENST00000450031 ENSP00000407404
ENST00000462608 ENSP00000441940
ENST00000480044
ENST00000461506
ENST00000497414
ENST00000465424
ENST00000465088
ENST00000480838
ENST00000493182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006508 proteolysis
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0043542 endothelial cell migration
GO:0051917 regulation of fibrinolysis
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031258 lamellipodium membrane
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0071438 invadopodium membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000392
View Gene Order
ENSBTAG00000008140
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.628667 Hs.654370
RefSeq NM_001291807 NM_004460
HUGO
OMIM
CCDS CCDS33311
HPRD 02674
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca