Version 5.4
Bos taurus Gene: FAP
Summary
InnateDB Gene IDBG-641224.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAP
Gene Name seprase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008140
Encoded Proteins
IDBP-693568
seprase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078098:
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:34297726-34376828
Strand Forward strand
Band
Transcripts
ENSBTAT00000010702 ENSBTAP00000010702
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0043542 endothelial cell migration
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0045177 apical part of cell
GO:0045178 basal part of cell
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000078098
View Gene Order
ENSMUSG00000000392
View Gene Order
Cross-References
SwissProt
TrEMBL A5D7B7
UniProt Splice Variant
Entrez Gene 508882
UniGene Bt.2717
RefSeq NM_001098001
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140497 DAAA02004416
GenPept AAI40498
RNA Seq Atlas 508882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca