InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sf3b4

Summary

InnateDB Gene

IDBG-174671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sf3b4

Gene Name

splicing factor 3b, subunit 4

Synonyms

49kDa; Sap49; SF3b49; SF3b50

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068856

Encoded Proteins

IDBP-174673

splicing factor 3b, subunit 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143368:
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:96172332-96177564

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000076372	ENSMUSP00000075709
ENSMUST00000153977

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	75 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding