InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hmgcr

Summary

InnateDB Gene

IDBG-174808.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcr

Gene Name

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Synonyms

HMG-CoAR; Red

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021670

Encoded Proteins

IDBP-174810

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623971

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623972

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623973

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623974

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623975

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623976

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

IDBP-623977

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113161:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:96648967-96670936

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022176	ENSMUSP00000022176
ENSMUST00000168855	ENSMUSP00000126087
ENSMUST00000169945	ENSMUSP00000128642
ENSMUST00000170287	ENSMUSP00000128939
ENSMUST00000169202	ENSMUSP00000132155
ENSMUST00000163201
ENSMUST00000169196	ENSMUSP00000132749
ENSMUST00000172440
ENSMUST00000169966	ENSMUSP00000128294
ENSMUST00000171537	ENSMUSP00000126959
ENSMUST00000168374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding
GO:0050662	coenzyme binding
GO:0070402	NADPH binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0006743	ubiquinone metabolic process
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0008299	isoprenoid biosynthetic process
GO:0008542	visual learning
GO:0010664	negative regulation of striated muscle cell apoptotic process
GO:0010666	positive regulation of cardiac muscle cell apoptotic process
GO:0015936	coenzyme A metabolic process
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0043066	negative regulation of apoptotic process
GO:0043407	negative regulation of MAP kinase activity
GO:0045445	myoblast differentiation
GO:0045471	response to ethanol
GO:0045908	negative regulation of vasodilation
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process
GO:0061045	negative regulation of wound healing
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle