Version 5.4
Mus musculus Gene: Atox1
Summary
InnateDB Gene IDBG-175293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atox1
Gene Name ATX1 (antioxidant protein 1) homolog 1 (yeast)
Synonyms AI256639; Atx1
Species Mus musculus
Ensembl Gene ENSMUSG00000018585
Encoded Proteins
IDBP-263652
ATX1 (antioxidant protein 1) homolog 1 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177556:
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:55446641-55461239
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000108857 ENSMUSP00000104485
ENSMUST00000138412
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0016531 copper chaperone activity
GO:0032767 copper-dependent protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0015680 intracellular copper ion transport
GO:0030001 metal ion transport
GO:0035434 copper ion transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177556
View Gene Order
ENSBTAG00000008340
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_189141
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_206069
Cellular responses to stress pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O08997
TrEMBL
UniProt Splice Variant
Entrez Gene 11927
UniGene
RefSeq NM_009720
OMIM
CCDS CCDS36158
HPRD
IMGT
MGI ID MGI:1333855
MGI Symbol Atox1
EMBL AF004591 AK002432 AL596207 BC027632
GenPept AAB61465 AAH27632 BAB22098 CAI35353
RNA Seq Atlas 11927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca