Version 5.4
Mus musculus Gene: Tnpo1
Summary
InnateDB Gene IDBG-176091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnpo1
Gene Name transportin 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000009470
Encoded Proteins
IDBP-262466
transportin 1
IDBP-262468
transportin 1
IDBP-714730
IDBP-715312
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083312:
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:98839019-98926384
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000109401 ENSMUSP00000105028
ENSMUST00000109399 ENSMUSP00000105026
ENSMUST00000179301 ENSMUSP00000136917
ENSMUST00000179271 ENSMUSP00000136496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000083312
View Gene Order
ENSBTAG00000007979
Not yet available
Pathways
NETPATH
REACTOME
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198689
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BFY9
TrEMBL J3QMX2 Q3TKD0 Q3TQW0
UniProt Splice Variant
Entrez Gene 238799
UniGene Mm.173286 Mm.466586 Mm.473481 Mm.486534 Mm.488217
RefSeq NM_001048267 XM_006517636 XM_006517637 XM_006517638 NM_178716
OMIM
CCDS CCDS36760 CCDS26717
HPRD
IMGT
MGI ID MGI:2681523
MGI Symbol Tnpo1
EMBL AC129085 AC154849 AK029953 AK030580 AK045132 AK163279 AK167049 BC031571 BC055372
GenPept AAH31571 AAH55372 BAC26696 BAC27029 BAC32236 BAE37272 BAE39215
RNA Seq Atlas 238799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca