InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Add3

Summary

InnateDB Gene

IDBG-176324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Add3

Gene Name

adducin 3 (gamma)

Synonyms

AI463285; R75380

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025026

Encoded Proteins

IDBP-176326

adducin 3 (gamma)

IDBP-176328

adducin 3 (gamma)

IDBP-257482

adducin 3 (gamma)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148700:
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:53140445-53247399

Strand

Forward strand

Band

Transcripts

ENSMUST00000050096	ENSMUSP00000052245
ENSMUST00000025999	ENSMUSP00000025999
ENSMUST00000111741	ENSMUSP00000107370

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005516	calmodulin binding

Biological Process

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000148700

View Gene Order

ENSBTAG00000003265

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9QYB5

TrEMBL

Q3UNK1 Q8BM29

UniProt Splice Variant

Entrez Gene

27360

UniGene

Mm.426080 Mm.472640

RefSeq

NM_001164100 NM_001164101 NM_001164099 NM_001277100 NM_013758

OMIM

CCDS

CCDS50467 CCDS29900

HPRD

IMGT

MGI ID

MGI:1351615

MGI Symbol

Add3

EMBL

AF100424 AF100425 AK019491 AK028481 AK035151 AK144174 BC037116 CH466585 DQ479918

GenPept

AAF24974 AAF24975 AAH37116 ABF48499 BAB31757 BAC25974 BAC28961 BAE25746 EDL01690

RNA Seq Atlas

27360