Version 5.4
| Mus musculus Gene: Siglec5 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-176568.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Siglec5 | ||||||||||
| Gene Name | sialic acid binding Ig-like lectin 5 | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000039013 | ||||||||||
| Encoded Proteins |
sialic acid binding Ig-like lectin 5
sialic acid binding Ig-like lectin 5
sialic acid binding Ig-like lectin 5
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation | |||||||||||
| Summary |
Siglec5 is a member of the rapidly evolving CD33-related siglec subfamily that are expressed on cells of the innate immune system. Siglec5 mediates endocytosis of anti-Siglec5 and sialoside ligands and Sigelc5 endocytosis is clathrin and dynamin independent, requires ADP ribosylation factor 6, and traffics to lysosomes.
Siglec5 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] SIGLEC5 is bound by group B Streptococcus (GBS) beta protein and this functions to impair human leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival.
[Homo sapiens] SIGLEC5 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105501:
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 7:43351341-43359531 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | B3 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Innate Immune System pathway
Immune System pathway
DAP12 interactions pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | Q80ZE2 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 233186 | ||||||||||
| UniGene | Mm.290569 Mm.412877 | ||||||||||
| RefSeq | NM_001271019 NM_145581 XM_006540816 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS21167 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:2681107 | ||||||||||
| MGI Symbol | Siglec5 | ||||||||||
| EMBL | AC149091 AY210401 | ||||||||||
| GenPept | AAO48274 | ||||||||||
| RNA Seq Atlas | 233186 | ||||||||||