InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Klk6

Summary

InnateDB Gene

IDBG-177611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klk6

Gene Name

kallikrein related-peptidase 6

Synonyms

AI849898; BSP; Bssp; Klk29; MSP; neurosin; Prss18; Prss9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050063

Encoded Proteins

IDBP-265561

kallikrein related-peptidase 6

IDBP-265563

kallikrein related-peptidase 6

IDBP-265565

kallikrein related-peptidase 6

IDBP-722806

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167755:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer\'s disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:43824499-43832027

Strand

Forward strand

Band

Transcripts

ENSMUST00000107968	ENSMUSP00000103602
ENSMUST00000107967	ENSMUSP00000103601
ENSMUST00000107966	ENSMUSP00000103600
ENSMUST00000177514	ENSMUSP00000135591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0010975	regulation of neuron projection development
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0070997	neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0030141	secretory granule
GO:0031965	nuclear membrane
GO:0045171	intercellular bridge

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000167755

View Gene Order

ENSBTAG00000030482

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3944

RefSeq

NM_001164696 NM_001164697 NM_001164698 NM_011177

OMIM

CCDS

CCDS21184

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas