InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cbr1

Summary

InnateDB Gene

IDBG-177870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbr1

Gene Name

carbonyl reductase 1

Synonyms

AW261796; Cbr; CR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051483

Encoded Proteins

IDBP-177872

carbonyl reductase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159228:
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:93607837-93610505

Strand

Forward strand

Band

Transcripts

ENSMUST00000039659

ENSMUSP00000049394

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0047021	15-hydroxyprostaglandin dehydrogenase (NADP+) activity
GO:0050221	prostaglandin-E2 9-reductase activity

Biological Process

GO:0008152	metabolic process
GO:0017144	drug metabolic process
GO:0030855	epithelial cell differentiation
GO:0042373	vitamin K metabolic process
GO:0055114	oxidation-reduction process