Version 5.4
Mus musculus Gene: Siah1a
Summary
InnateDB Gene IDBG-178087.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siah1a
Gene Name seven in absentia 1A
Synonyms AA982064; AI853500; Sinh1a
Species Mus musculus
Ensembl Gene ENSMUSG00000036840
Encoded Proteins
IDBP-178089
seven in absentia 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11742346
[Homo sapiens] SIAH1 is a ubiquitin ligase structurally related to TRAF and modulates TNF-alpha signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196470:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson\'s disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:86723940-86746006
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000045296 ENSMUSP00000044123
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007141 male meiosis I
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0009791 post-embryonic development
GO:0030154 cell differentiation
GO:0040014 regulation of multicellular organism growth
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196470
View Gene Order
ENSBTAG00000010868
Not yet available
Pathways
NETPATH
REACTOME
REACT_229826
Netrin-1 signaling pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04115
p53 signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P61092
TrEMBL
UniProt Splice Variant
Entrez Gene 20437
UniGene Mm.324553
RefSeq NM_009172
OMIM
CCDS CCDS22504
HPRD
IMGT
MGI ID MGI:108064
MGI Symbol Siah1a
EMBL BC046317 Z19579
GenPept AAH46317 CAA79630
RNA Seq Atlas 20437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca