InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.37798

Summary

InnateDB Gene

IDBG-631496.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.37798

Gene Name

E3 ubiquitin-protein ligase SIAH1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010868

Encoded Proteins

IDBP-683033

seven in absentia homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 11742346

[Homo sapiens] SIAH1 is a ubiquitin ligase structurally related to TRAF and modulates TNF-alpha signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196470:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson\'s disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:16836726-16841714

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000053788

ENSBTAP00000052492

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007275	multicellular organismal development
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway