InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rchy1

Summary

InnateDB Gene

IDBG-179221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rchy1

Gene Name

ring finger and CHY zinc finger domain containing 1

Synonyms

ARNIP; CHIMP; Pirh2; Zfp363; Znf363

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029397

Encoded Proteins

IDBP-179223

ring finger and CHY zinc finger domain containing 1

IDBP-625061

ring finger and CHY zinc finger domain containing 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:91948904-91963068

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031345	ENSMUSP00000031345
ENSMUST00000140670
ENSMUST00000138351
ENSMUST00000169948	ENSMUSP00000131270

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination