InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RCHY1

Summary

InnateDB Gene

IDBG-643046.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCHY1

Gene Name

RING finger and CHY zinc finger domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007189

Encoded Proteins

IDBP-695566

RING finger and CHY zinc finger domain-containing protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163743:
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:92061508-92076962

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009461

ENSBTAP00000009461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination