Version 5.4
Mus musculus Gene: Aph1b
Summary
InnateDB Gene IDBG-179986.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aph1b
Gene Name anterior pharynx defective 1b homolog (C. elegans)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032375
Encoded Proteins
IDBP-179988
anterior pharynx defective 1b homolog (C. elegans)
IDBP-253276
anterior pharynx defective 1b homolog (C. elegans)
IDBP-621978
anterior pharynx defective 1b homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138613:
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:66775202-66795490
Strand Reverse strand
Band C
Transcripts
ENSMUST00000034934 ENSMUSP00000034934
ENSMUST00000113730 ENSMUSP00000109359
ENSMUST00000168309 ENSMUSP00000125816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007219 Notch signaling pathway
GO:0016485 protein processing
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000138613
View Gene Order
Pathways
NETPATH
REACTOME
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_189085
Disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_196589
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_243590
EPH-ephrin mediated repulsion of cells pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199412
Signaling by NOTCH2 pathway
REACT_199413
Signaling by NOTCH3 pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199411
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199404
Signaling by NOTCH4 pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_261444
Axon guidance pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_218614
Regulated proteolysis of p75NTR pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_202271
NRIF signals cell death from the nucleus pathway
REACT_231152
Signaling by NOTCH pathway
REACT_196591
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
mmu04330
Notch signaling pathway pathway
mmu05010
Alzheimer's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_13443
Regulated proteolysis of p75NTR pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_118636
Signaling by NOTCH4 pathway
REACT_118862
Signaling by NOTCH3 pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_116125
Disease pathway
KEGG
hsa04330
Notch signaling pathway pathway
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
p75ntrpathway
p75(NTR)-mediated signaling
syndecan_3_pathway
Syndecan-3-mediated signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt Q8C7N7
TrEMBL F8WHK7 Q3TRQ2
UniProt Splice Variant
Entrez Gene 208117
UniGene Mm.41291 Mm.473445
RefSeq NM_177583 XM_006510922
OMIM
CCDS CCDS23307
HPRD
IMGT
MGI ID MGI:3522097
MGI Symbol Aph1b
EMBL AC134429 AC142504 AK028521 AK049828 AK154847 AK162585 BC079659 CH466522
GenPept AAH79659 BAC25988 BAC33940 BAE32873 BAE36975 EDL26128
RNA Seq Atlas 208117

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca