InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Med4

Summary

InnateDB Gene

IDBG-180055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med4

Gene Name

mediator of RNA polymerase II transcription, subunit 4 homolog (yeast)

Synonyms

2410046H15Rik; DRIP36; HSPC126; TRAP36; Vdirp; Vdrip

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022109

Encoded Proteins

IDBP-180057

mediator of RNA polymerase II transcription, subunit 4 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136146:
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:73510049-73518545

Strand

Forward strand

Band

Transcripts

ENSMUST00000022705

ENSMUSP00000022705

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated