InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MED4

Summary

InnateDB Gene

IDBG-629063.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED4

Gene Name

Mediator of RNA polymerase II transcription subunit 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019502

Encoded Proteins

IDBP-680457

Mediator of RNA polymerase II transcription subunit 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136146:
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:17973731-17988210

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025979

ENSBTAP00000025979

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated